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Medication Names
spironolactone (Aldactone®)
eplerenone (Inspra®)
Spironolactone is prescribed in low doses for people with advanced systolic heart failure to improve outcomes and to prevent symptoms from becoming worse. Eplerenone is prescribed for patients who develop left ventricular dysfunction (an ejection fraction of less than or equal to 40%) following a heart attack. When given early after a heart attack, it may prevent heart muscle damage from worsening. Both spironolactone and eplerenone block a certain chemical (aldosterone) in the body that causes salt and fluid build-up and stiffening of the heart muscle.
Follow the label directions on how often to take these medications. The number of doses you take each day, the time allowed between doses, and how long you need to take the medication will depend on your condition. These medications can be taken with or without food.
Before these medications are prescribed, tell your doctor or nurse if you have diabetes, kidney disease, liver disease, gout, a history of kidney stones, menstrual problems, breast enlargement (in men), and/or high potassium (hyperkalemia).
These medications are generally prescribed in combination with other heart failure medications. If you experience an increase in side effects after taking your medications together, contact your doctor or nurse. You may need to change the times you are taking each medication.
Before these medications are prescribed, tell your doctor or nurse if you are taking medications for high blood pressure, cyclosporine, potassium-containing medications, digoxin, lithium, or arthritis medications such as ibuprofen.
Follow your health care provider’s dietary advice, including:
Do not use salt substitutes, as they contain potassium and these medications can cause the body to retain potassium. Learn how to read food labels so you can identify the potassium content. A dietitian can help you select the appropriate foods.
Contact your doctor or nurse right away if you have any other symptoms that cause concern.
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